Synthesis and anti-microbial activities of azomethine and aminomethyl phenol derivatives

doi:10.33945/sami/ajgc/2019.4.7

Abstract

A series of azomethine and aminomethyl phenol derivatives has been synthesized and characterized by mass, IR, and NMR spectral techniques.In vitro antimicrobial activities of all these compounds were evaluated against different gram-positive and gram-negative bacterial and fungal strains by measuring zone of inhibition using agar diffusion method. Results of antimicrobial screening indicated that the compound 4a was the most active antimicrobial agent (100 µg/mL). The compounds 3a, 4e, 4f were exhibited best in vitro anti-microbial activity against the gram positive bacterial strains such as Bacillus subtilis, Micrococcus luteus and gram negativebacterialstrain Salmonella typhi andfungalstrain Candida albicans.

Highlights

The development of newer antibacterial and fungal drugs is necessary as the pathogens evolve resistance against the available drugs
The results showed that most of the synthesized molecules exhibited potent antimicrobial activity
The azomethine [14‒20] and aminomethyl phenol derivatives [21‒24] were synthesized by following a well-established protocol

Summary

Introduction

The development of newer antibacterial and fungal drugs is necessary as the pathogens evolve resistance against the available drugs. 4f a To the formed azomethine (1 eq) in dry ethanol (10 vol) sodium borohydride (1.0 eq) was added in portions over a period of 20 min at 0 °C under N2 atmosphere. To the formed azomethine (1 eq) in dry ethanol (10 vol) sodium borohydride (1.0 eq) was added in portions over a period of 20 min at 0 °C under N2 atmosphere b The yields are of isolated yields.

Results

Conclusion