Abstract
In order to prepare new antiepileptic drugs with a broader clinical application and lower toxic side effects, we have employed esterification and condensation reactions (we call it Niche Chemistry) to reduce the use of valproic acid as the target molecule. In combination with the study of a broad‐spectrum of novel anticonvulsants, we have synthesized two valeric acid derivative compounds [(4‐acetamidophenyl 2‐propylvalerate (1), and (E)‐5‐(4‐((2‐propylpentanoyl)oxy)styryl)‐1,3‐phenylene bis(2‐propylvalerate) (2) by an esterification reaction. The maximum shock seizure test for products 1 and 2 has been successfully carried out, and their cytotoxic activity and survival effects have also been carefully investigated.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
