Abstract
A series of N -(2-benzoylbenzofuran-3-yl)-4-(substituted)butanamides ( IIIa-f ) were synthesized in good yield and evaluated for anticonvulsant activity and neurotoxic study. The identity of the synthesized compounds was confirmed on the basis of their elemental analysis and spectral data. In anti-MES test compounds IIIb, IIIc, IIId and IIIf showed potent activity. Compounds IIIa and IIIe were less toxic as compared with the standard drug phenytoin.
Highlights
Since the past few decades, the literature has been enriched with progressive findings about the synthesis and pharmacological activities of various substituted benzofuran derivatives
The field of antiepileptic drug development (ADD) has become quite dynamic, affording many promising research opportunities, and there is a continuing demand for new anticonvulsant agents as it has not been possible to control every kind of seizure with currently available antiepileptic drugs
Compounds in Table 1. N-(2-benzoylbenzofuran-3-yl)-4-(4-(furan-2carbonyl)piperazin-1-yl)butanamide (IIIa) and IIIe were toxic at the dose of 300 mg/kg after 0.5 hr. and 4 hr
Summary
Since the past few decades, the literature has been enriched with progressive findings about the synthesis and pharmacological activities of various substituted benzofuran derivatives. There has been intense investigation of different classes of benzofuran compounds and many of them were found to be pharmacologically active.
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