SYNTHESIS AND ANTIBACTERIAL EVALUATION OF 3-ARYL INDAZOLES

Abstract

A series of 3-aryl indazoles 4a-4j were obtained by Pd catalyzed Suzuki coupling reaction. All the substrates were obtained in good yields under moderate reaction conditions. Next, the prepared compounds 4a-4j were screened for their antibacterial activity. The anti-bacterial activities of the prepared compounds were investigated against three bacterial strains i.e. Xanthomonas campestris, Escherichia coli, Bacillus megaterium. The anti-bacterial evaluation studies of these 3-aryl indazoles revealed that some of these test compounds possess moderate in vitro antibacterial activity.