Efficient synthesis of fluorinated biphenyl derivatives via Pd-catalyzed Suzuki coupling reactions in aqueous solvents at room temperature

Abstract

A variety of fluorinated biphenyl derivatives were obtained in good yields in aqueous solvents at room temperature by Suzuki coupling reaction of aryl bromides and aryl boronic acid in the presence of high activity catalyst—some air-stable hemilabile P O coordinated cyclopalladated complexes. The structures of above catalysts were characterized by element analyses, IR, 1H NMR, 13C NMR and 31P NMR.