Abstract
All stereoisomers of 1,3-polyol/α-pyrone 1-8 with more than 99% ee were synthesized to estimate the effect of stereochemistry on the antifungal activity. The absolute configuration of natural compound was determined as (6R,2'S,4'R)-2. The eight stereoisomers showed the antifungal activity against plant pathogenic Alternaria alternata Japanese pear pathotype and Colletotrichum lagenarium. The large difference of activity level was not observed between stereoisomers, showing 43-72% of growth ratio against control at 0.5mM. The most potent stereoisomer was (6S,2'S,4'S)-8 and the activity of (6R,2'S,4'S)-1 was weakest against both fungi.
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