Abstract
5-Alkylamino-2-thiobarbituric acid derivatives containing a p-substituted phenyl group in the nitrogen were synthesized in order to examine the presence of analgesic action in a compound by the introduction of two kinds of atom group, one having a pyrolytic and the other hypnotic activity, in one molecule. Attempt for further introduction of an alkyl group in the carbon atom at 5-position failed. Pharmacological test of 19 kinds of the barbituric acid derivatives synthesized showed that none of them had a strong analgesic action.
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Schedule a callMore From: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
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