Abstract
A series of novel pyrazolo [4, 3-d] pyrimidin-7-ones was designed and synthesized in order to find new potent phosphodiesterase 5 inhibitors (PDE5). The structures of all the compounds were confirmed by IR, 1 H NMR and MS; their in vitro vasodilatory activities were tested on isolated rabbit aortic spiral strips. Among them, compound X3 displays a significant vasodilatory activity, which is more potent than verapamil.
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