Abstract
Moringa stenopetala has nutritional and medicinal values, which is widely used by the local communities. The study aimed to evaluate the antihyperglycemic, vasodilator, and diuretic activities of the microencapsulated bioactive product from M. stenopetala leaves extract. Microencapsulation of the extract was done by spray drying technique using maltodextrin and pectin as coating materials with the core: coating ratio of 1 : 6. Then, the antihyperglycemic, diuretic, and vasodilator activities were evaluated after the product was administered to experimental animals at different doses and compared with the control groups. There were no observed physical, behavioral, and physiological changes on the mice during the acute toxicity test. The results also indicated no toxicity signs and death occurrence in the experimental animals up to 5000 mg/kg administered dose. Therefore, microencapsulated M. stenopetala leaves extract does not produce adverse effects in experimental mice. The study also showed that the microencapsulated bioactive product exhibited significant antihyperglycemic, vasodilator, and diuretic activities as the doses increase. Therefore, the study showed that microencapsulated bioactive product has significant medicinal values. Further detailed studies are recommended on chronic toxicity tests and to understand the possible mechanism of actions on the antihyperglycemic, vasodilator, and diuretic activities of the microencapsulated product.
Highlights
Moringa stenopetala plant has biologically active compounds that have beneficial medicinal attributes in addition to food sources and feed
Considering the medicinal importance of M. stenopetala, the leaves extract was formulated into microencapsulate using spray drying technology. is study, aimed to evaluate the antihyperglycemic, diuretic, and vasodilator activities of the microencapsulated product of the extract of M. stenopetala leaves
In Vitro Vasodilator Activity Test. e in vitro vasodilatory activity of the microencapsulated product of M. stenopetala leaves extract was done using isolated guinea pig thoracic aorta according to the methods described by Vogel [22]. e guinea pig was sacrificed by gentle cervical dislocation and the thoracic cavity was opened to identify the aorta. e descending thoracic aorta was taken and placed in Krebs physiological solution maintained at 37°C
Summary
Antihyperglycemic, Vasodilator, and Diuretic Activities of Microencapsulated Bioactive Product from Moringa stenopetala Leaves Extract. E study aimed to evaluate the antihyperglycemic, vasodilator, and diuretic activities of the microencapsulated bioactive product from M. stenopetala leaves extract. En, the antihyperglycemic, diuretic, and vasodilator activities were evaluated after the product was administered to experimental animals at different doses and compared with the control groups. Erefore, microencapsulated M. stenopetala leaves extract does not produce adverse effects in experimental mice. E study showed that the microencapsulated bioactive product exhibited significant antihyperglycemic, vasodilator, and diuretic activities as the doses increase. Erefore, the study showed that microencapsulated bioactive product has significant medicinal values. Further detailed studies are recommended on chronic toxicity tests and to understand the possible mechanism of actions on the antihyperglycemic, vasodilator, and diuretic activities of the microencapsulated product
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