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https://doi.org/10.1016/j.bmcl.2010.04.105
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Cite Publication Date: Apr 28, 2010 | |
 Citations: 13 |
Affiliation: Abbott Fund, NeuroSearch (Denmark)
Biaryl substituted 2,5-diazabicyclo[2.2.1]heptanes have been synthesized and tested for their affinity toward α7 neuronal nicotinic receptors (NNRs). SAR studies established that 5-N-methyl substituent, heteroaryl linker and the nature of terminal aryl group are critical for the ligand to achieve potent α7 NNR agonist activity.
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