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PDF Availablehttps://doi.org/10.1136/ard.2009.107466
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Cite Journal: Annals of the Rheumatic Diseases |  Publication Date: Jun 22, 2009 |
 Citations: 59 |  License type: open-access |
Affiliation: University of Birmingham, Erasmus MC, Orthopaedic Hospital
ObjectivesSynovial fibroblasts and osteoblasts generate active glucocorticoids by means of the 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme. This activity increases in response to proinflammatory cytokines or glucocorticoids. During inflammatory arthritis...
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