Synergistic Antidiabetic and Antihyperlipidaemic Activity of Glibenclamide by Integrating Momordica charantia Fruit Juice in Streptozotocin Induced Diabetic Rat

Abstract

Diabetes mellitus is among the most common disorder in developed and developing countries, and the disease is increasing rapidly in most parts of the world. It has been estimated that up to one-third of patients with diabetes mellitus use some form of complementary and alternative medicine. The aim of the present study was to evaluate synergistic antidiabetic and antihyperlipidaemic effects of Momordica charantia fruit juice along with Glibenclamide (lower dose) on glucose tolerance and lipid profile in streptozotocin induced diabetic rat. The Momordica charantia fruit juice (MCFJ) were prepared and different combination of MCFJ and Glibenclamide was evaluated for antidiabetic activity in experimental animals. The administration of MCFJ along with Glibenclamide significantly decreased the blood glucose levels compared to control diabetic rats. The MCFJ along with Glibenclamide significantly lowered the elevated total cholesterol, triglycerides (TGL), total protein and low density lipoprotein (LDL) level while increased the high density lipoprotein (HDL) indicates the antihyperlipidaemic activity. The findings demonstrated the MCFJ enhanced antidiabetic and antihyperlipidaemic activity of Glibenclamide and produced higher protective effect from diabetes.