Synergism of factors contributing to the development of gastric development of gastric ulcer and gastric cancer

Abstract

Aimto study to compare the factors contributing to the development of gastric ulcer and gastric cancer in the population of the Republic of Khakassia. Materials and methods. Epidemiological screening of the ulcer was carried out by the simultaneous transverse method (n = 4217) using endoscopy, morphological, rapid urease, serological and PCR for biopsy testing of H. pylori. Patients were selected by 25% random sampling. Retrospectively investigated the epidemiological parameters of the GC (2295 patients) 2002-2017. Risk factors were studied by questioning patients with a newly established diagnosis (2018-2019). Results. The prevalence of ulcer was 8.9% in Caucasians and 4.5% in Khakasses, p <0.001. The incidence of pancreatic cancer in men is 2 and 1.28 times higher than in women, respectively. With age, the incidence of ulcer and cancer increased. The association of H. pylori with peptic ulcer is registered in both populations. Among patients with gastric cancer, 78% of respondents had H. pylori-positive status, 18% of patients had a combination with peptic ulcer. Tobacco smoking had a pronounced direct relationship with ulcerogenesis. The incidence of peptic ulcer in smokers of more than 10 packs/year of Caucasians was 17.0%, Khakasses - 17.2%, p <0.001. Among patients with gastric cancer, the fact of smoking was found in 45% of respondents; the proportion of men is 3 times more than women. Conclusion In the population of the Republic of Khakassia, conventional risk factors for peptic ulcers, such as male gender, increasing age, tobacco smoking, and H. pylori infection, are also predictors of the development of stomach cancer