Abstract
We report two cases of atypic defibrination syndroms in patients with respectively acute monoblastic leukemia (chronic myeloid leukemia initially) and acute lymphoblastic leukemia. Hemostasis studies show low fibrinogen level, elevated D-dimeres, decreased α2 antiplasmin and factor V, normal antithrombin III values. Plasminogen is below the normal range in one patient. Solubles complexs, which are an important argument for diagnosis of intravascular coagulation disease, are not detected in both patients. Primitive or secondary hyperfibrinolysis seems also excluded since euglobulin clot lysis time was normal. Enzymatic proteolysis of fibrinogen (or fibrin) by the blasts cells has been reported by some authors; this mechanism could account for the hemostasis abnormalities observed in these two partients.
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