Synaptonemal complexes in Gerbillidae: probable role of intercalated heterochromatin in gonosome-autosome translocations.

Abstract

A study of sex chromosomes and synaptonemal complexes in male specimens of Gerbillus chiesmani, G. nigeriae, G. hoogstrali, and Taterillus pygargus is reported. In each of these Gerbillidae species there are two or three translocations of autosomes with X and Y chromosomes. Analysis of mitotic chromosomes consistently shows the presence of constitutive heterochromatin on the der t(X;autosome) at the X-autosome junction and on the der t(Y;autosome). Analysis of the synaptonemal complexes shows the existence of an unusual structure, lightly stained, at the X-autosome junction and at the Y-autosome junction, which is probably heterochromatic in nature, thus corresponding to the mitotic patterns. This heterochromatin separates the autosomal and gonosomal segments, which behave independently and normally. By analogy with findings from humans and other mammals, a general hypothesis is proposed on the role of intercalated heterochromatin between translocated gonosomes and autosomes. This hypothesis explains why the pathological consequences of these translocations may be very different in males and females. The role of intercalated heterochromatin would be to avoid the pathological consequences of gonosome-autosome translocations resulting from inactivation of the sex chromosomes in female somatic cells and male germinal cells.