Synaptic transmission in suprasylvian visual cortex is reduced by excitatory amino acid antagonists.

Abstract

The activities of cortical neurones lying in the Clare-Bishop area of the suprasylvian visual region in anaesthetized cats were monitored during the application of cholinergic and amino acid agonists and antagonists, as well as during sequences of light and electrical stimulation. Of those Clare-Bishop cells which could be activated at short latencies by electrical stimuli applied to the contralateral, homologous cortical zone, D-alpha-aminoadipate and 2-amino-5-phosphonovalerate antagonized neuronal responses elicited by electrically evoked synaptic activation and by the presentation of light stimuli. Acetylcholine as well as the excitatory amino acids increased the firing of many of these neurones; however only the amino acid antagonists blocked the commissurally evoked excitations although both types of antagonist reduced the magnitudes of the visually evoked responses. It therefore appears as though the same synaptic transmitter is utilized by cortical commissural afferents as is employed by the cortical ipsilateral projection to the Clare-Bishop area, and furthermore this transmitter is likely to be an excitatory amino acid.