Abstract
This study aimed to assess the utility of echocardiography-measured EAT tickness (EATT) as an independent predictor for CAD, examining its correlation with oxidative stress levels in epicardial tissue and the complexity of the disease in patients undergoing open-heart surgery. This study included a total of 25 patients referred for cardiac surgery with 14 in the CAD group and 11 in the non-CAD group. Epicardial fat was sampled from patients subjected to open-heart surgery. EATT was higher in the CAD group compared to the non-CAD group (8.15±2.09 mm vs. 5.12±1.8 mm, p=0.001). The epicardial ROS level was higher in the CAD group compared to the non-CAD group (21.4±2.47 nmol H2O2/g tisssue/h vs. 15.7±1.55 nmol H2O2/g tisssue/h, p<0.001). EATT greater than 6.05 mm was associated with CAD, with a sensitivity of 86% and specificity of 73%. Echocardiographically measured EATT is a significant, independent predictor of CAD. Its relationship with increased EAT oxidative stress levels suggests a potential mechanistic link between EATT and CAD pathogenesis. These findings highlight the importance of EATT as a diagnostic tool in assessing the complexity of CAD in patients undergoing cardiac surgery.
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