Abstract
The 1D 1 H NOE difference spectra of 50 base- and/or sugar-modified nucleosides were measured in (CD 3 ) 2 SO with irradiation of various protons. The resulting NOE data were used for a conformational analysis with respect to their syn-anti conformer equilibrium. Measurement of the NOE spectra of sterically hindered nucleosides implied that both the chemical properties as well as the van der Waals radius of nucleobase substituent are of decisive importance for the conformation around the N-glycosylic bond
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