Symptomatology and course of COVID-19 infection among vaccinated and unvaccinated pregnant women admitted to a referral hospital

Abstract

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by a novel strain of Coronavirus (2019-nCoV). India is one of country which is largely affected by COVID-19 during 1st and 2nd wave of COVID-19. This study includes the pregnant women who are vaccinated before pregnancy or antenatally, who later developed COVID 19 infection. In these women interval between vaccination and COVID 19 positive, and outcome among vaccinated.Methodology: 3 months prospective hospital based cross sectional study in designated COVID hospital under care of Government Maternity Hospital, Tirupati, to compare outcome of pregnant women with COVID 19 infection who are vaccinated to the unvaccinated pregnant women. Sample size was 27.Results: From the present study it can be seen that the course of COVID 19 infection is mild in case of fully vaccinated women and stormy in case of some unvaccinated women but even partial vaccination with one dose offers some amount of protection from morbidity and mortality.Conclusion: Because these studies were carried out in months of July, august, September, most of women could receive only first dose. The sample size in this study is a limitation. We need studies with a larger vaccinated population to draw solid conclusions. There is also need for separate studies regarding different brands of vaccine.