Abstract
BackgroundMultiple pathological manifestations are rarely present in patients with primary hyperparathyroidism (PHPT). Here we described a case of a young woman who presented with multiple skeletal destructions and received an unclear diagnosis at several hospitals.Case presentationA 30-year-old woman was admitted to our hospital due to pain in both knees and walking difficulty that lasted for 6 and 2 years, respectively. Her laboratory test results revealed a high parathyroid hormone level (822 pg/ml) and hypercalcemia (2.52 mmol/L) in the blood. Parathyroid imaging revealed a lumpy concentration of radioactive uptake detected at the lower pole in the right lobe of the thyroid, and was nearly 2.2 cm * 2.4 cm in size. Next, the patient was treated with parathyroidectomy that resulted in a significant improvement in physiological and clinical symptoms. Moreover, the skeletal destruction and bone mineral density were significantly improved after a 5-years follow-up period.ConclusionsMultiple skeletal destructions can be caused by PHPT that should be taken into consideration in young patients with complex bone lesions.
Highlights
Multiple pathological manifestations are rarely present in patients with primary hyperparathyroidism (PHPT)
Multiple skeletal destructions can be caused by PHPT that should be taken into consideration in young patients with complex bone lesions
Primary hyperparathyroidism (PHPT) is a rare clinical condition characterized by an autonomic oversecretion of parathyroid hormone caused by a parathyroid adenoma, hyperplasia, or cancer [1, 2]
Summary
Multiple pathological manifestations are rarely present in patients with primary hyperparathyroidism (PHPT). Conclusions: Multiple skeletal destructions can be caused by PHPT that should be taken into consideration in young patients with complex bone lesions. We described a case of a young woman who presented with multiple skeletal destructions and received an unclear diagnosis at several hospitals.
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