Abstract
BackgroundStudies have shown that the response of bone mineral density (BMD) to parathyroidectomy for symptomatic primary hyperparathyroidism (PHPT) is heterogeneous and difficult to predict. However, the independent factors affecting BMD in PHPT patients after parathyroidectomy remains limited and inconclusive. This study aimed to explore the independent factors affecting BMD changes in symptomatic PHPT patients after parathyroidectomy.MethodsThis study retrospectively analyzed 105 patients with symptomatic PHPT treated at Beijing Jishuitan Hospital between January 2010 and December 2015. The primary outcome was a > 10% increase in BMD at 3 years after parathyroidectomy compared with the preoperative value, whereas the secondary outcomes were BMD changes at various measurement sites.ResultsA total of 105 patients with a mean age of 46.37 years were included in this study. Univariate logistic regression analysis indicated that hypertension (odds ratio [OR[: 0.032; 95% confidence interval [CI]: 0.001–0.475; P = 0.012), and parathyroid hormone level (OR: 1.006; 95% CI: 1.004–1.009; P = 0.044) were associated with the > 10% BMD increase. However, these results were not significant after adjustments for potential confounders. Moreover, the BMD values at the lumbar spine, femoral neck, femoral trochanter, Ward’s triangle, and whole body after parathyroidectomy were significantly greater than those before the operation (P < 0.05).ConclusionsThis study suggests that patient characteristics were not associated with the > 10% BMD increase. However, the BMD values of the femur and lumbar spine were significantly increased in symptomatic PHPT patients after parathyroidectomy.
Highlights
Studies have shown that the response of bone mineral density (BMD) to parathyroidectomy for symptomatic primary hyperparathyroidism (PHPT) is heterogeneous and difficult to predict
PHPT is significantly associated with hypercalcemia and high parathyroid hormone (PTH) levels, which could promote calcium reabsorption in the distal renal tubules and alter the conversion of 25(OH)-vitamin D to 1,25(OH)2-vitamin D through 1α-hydroxylase stimulation [9]
This study aimed to explore the potential effect of patients’ characteristics on BMD values before and after parathyroidectomy in patients with symptomatic PHPT
Summary
Studies have shown that the response of bone mineral density (BMD) to parathyroidectomy for symptomatic primary hyperparathyroidism (PHPT) is heterogeneous and difficult to predict. The independent factors affecting BMD in PHPT patients after parathyroidectomy remains limited and inconclusive. This study aimed to explore the independent factors affecting BMD changes in symptomatic PHPT patients after parathyroidectomy. Primary hyperparathyroidism (PHPT) is the third most common endocrine disorder, with a prevalence ranging from 0.1 to 0.7% in adults [1,2,3] It remains a common cause of hypercalcemia and predominantly affects the elderly, especially women [4]. This study aimed to explore the potential effect of patients’ characteristics on BMD values before and after parathyroidectomy in patients with symptomatic PHPT. The changes in BMD at various sites before and after parathyroidectomy in patients with symptomatic PHPT were compared
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