Abstract
We analyze numerically the problem of spontaneous symmetry breaking and migration of a three-dimensional vesicle [a model for red blood cells (RBCs)] in axisymmetric Poiseuille flow. We explore the three relevant dimensionless parameters: (i) capillary number, Ca, measuring the ratio between the flow strength over the membrane bending mode, (ii) the ratio of viscosities of internal and external liquids, λ, and (iii) the reduced volume, ν=[V/(4/3)π]/(A/4π)3/2 (A and V are the area and volume of the vesicle). The overall picture turns out to be quite complex. We find that the parachute shape undergoes spontaneous symmetry-breaking bifurcations into a croissant shape and then into slipper shape. Regarding migration, we find complex scenarios depending on parameters: The vesicles either migrate towards the center, or migrate indefinitely away from it, or stop at some intermediate position. We also find coexisting solutions, in which the migration is inwards or outwards depending on the initial position. The revealed complexity can be exploited in the problem of cell sorting out and can help understanding the evolution of RBCs' in vivo circulation.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Physical review. E, Statistical, nonlinear, and soft matter physics
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
