Abstract
BackgroundIt has been shown that irisin levels are reduced in skeletal muscle and plasma of obese rats; however, the effect of exercise training on irisin level remains controversial. We aim to evaluate the association of swimming exercise with serum irisin level and other obesity-associated parameters.MethodsForty healthy male Wistar rats were randomly assigned to 4 groups: a normal diet and sedentary group (ND group), normal diet and exercise group (NDE group), high-fat diet and sedentary group (HFD group), and high-fat diet and exercise group (HFDE group. After 8 consecutive weeks of swimming exercise, fat mass and serum irisin level was determined.ResultsHigher serum irisin levels were detected in the HFDE group (1.15 ± 0.28 μg/L) and NDE group (1.76 ± 0.17 μg/L) than in the HFD group (0.84 ± 0.23 μg/L) or the ND group (1.24 ± 0.29 μg/L), respectively (HFDE group vs. HFD group, P < 0.05; NDE group vs. ND group, P < 0.01). Pearson’s correlation analysis showed that serum irisin level negatively correlated with TG level (r = −0.771, P < 0.05), percentage fat mass (r = −0.68, P < 0.05), fat mass (r = −0.576, P < 0.05), visceral fat mass (r = −0.439, P < 0.05) and TC level (r = −0.389, P < 0.05). The fat mass, visceral fat mass and percentage fat mass were lower in the HFDE group than the HFD group (all P values < 0.01).ConclusionSwimming exercise decreases body fat mass in high-fat-fed Wistar rats, which may be attributable to elevated irisin levels induced by swimming exercise.
Highlights
It has been shown that irisin levels are reduced in skeletal muscle and plasma of obese rats; the effect of exercise training on irisin level remains controversial
Abdominal circumference, Lee’s index and total cholesterol (TC) level were higher in the high-fat diet and sedentary group (HFD) and high-fat diet and exercise group (HFDE) than in the normal diet and sedentary group (ND) and normal diet and exercise group (NDE) after 8 weeks of diet feeding, and higher body weight, abdominal circumference, Lee’s index, TC and triglyceride (TG) levels were all recorded in the HFD and HFDE groups compared to the ND and NDE groups at 16 weeks
At 24 weeks, Lee’s index, TG and TC levels were lower in the HFDE group than in the HFD group; the body weight, abdominal circumference, low-density lipoprotein (LDL) concentration, fasting blood glucose (FBG) and serum insulin level exhibited lower in the HFDE group than those in the HFD group, no statistically significant differences were observed in body weight among the three groups
Summary
It has been shown that irisin levels are reduced in skeletal muscle and plasma of obese rats; the effect of exercise training on irisin level remains controversial. We aim to evaluate the association of swimming exercise with serum irisin level and other obesity-associated parameters. Regular physical activity is found to play a key role in reducing the risk of obesity by increasing energy expenditure, the detailed mechanism of which remains unclear. A novel hormone secreted by muscle identified in 2012, Lu et al Lipids in Health and Disease (2016) 15:93 fibronectin type III domain containing 5 (FNDC-5) or plasma irisin in obese rats [3]. The major purpose of this study was to evaluate the association of swimming exercise with serum irisin level and other obesity-associated parameters in high-fat-diet fed Wistar rats
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
