Abstract
Objective To investigate the association of serum irisin level with fat mass percentage. Methods A total of 1204 subjects with obesity(waist circumference: male ≥90 cm, female ≥85 cm) were recruited from Lianqian Community in Xiamen city from April, 2011 to August, 2012. All the participants received questionnaire survey, physical examination, blood chemistry tests and serum irisin levels measurement, and the fat mass percentage was measured by using a bioelectrical impedance analyzer. The data were analyzed using student-t test, ANOVA and logistic regression. Results Total of 807 women and 397 men with central obesity took part in the study, the age was (53±7) yrs(35 to 65 yrs). A higher fat mass percentage and serum irisin levels were shown in women as compared with those in men ((39±4)% vs (26±4)% and 8.9(4.7-17.2) μg/L vs 7.6(4.0-14.4) μg/L, t=-53.50, -2.87, both P<0.05). Serum irisin levels were correlated with fat mass percentage in total subjects. Fat mass percentage, serum total cholesterol(TC) and low density lipoprotein-cholesterol (LDL-C) levels increased as serum irisin levels increased by tertiles (F=4.49, 3.63, 4.88, all P for trend<0.05). Serum irisin levels were increased as fat mass percentage increased by tertiles (F=3.33, P<0.05). Logistic regression analysis showed that serum irisin levels were increase by 13% as fat mass percentage increased by one percent after all metabolic markers (such as age, sex, body mass index, waist circumference, physical activity, systolic blood pressure, diastolic blood pressure, current smoking and drinking, triglyceride, TC, LDL-C, high density lipoprotein-cholesterol, glycated hemoglobin A1c, fasting blood glucose and homeostasis model of assessment for insulin resistence index) were adjusted (OR=1.13, 95%CI: 1.01-1.25, χ2=4.83, P<0.05). Conclusions Serum irisin levels in obese adults were associated with fat mass percentage. Key words: Obesity; Irisin; Fat mass percentage
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