Abstract
BackgroundTo report the thickness of the retina, retinal ganglion cell (RGC)-related layers, and choroid in healthy subjects using swept source optical coherence tomography (SS-OCT).MethodsOne hundred and forty-six healthy volunteers were consecutively recruited for this prospective observational study. Thickness of retina, RGC-related layers, and choroid in the standard early treatment of diabetic retinopathy study (ETDRS) grid were automatically measured using one SS-OCT (DRI OCT-1, Topcon, Japan). The IOL Master (Carl Zeiss Meditec, Germany) was used to measure axial length (AL).ResultsThicknesses of the average macular ganglion cell complex (GCC) and ganglion cell-inner plexiform layer (GCIPL) were 105.3 ± 9.7 and 78.5 ± 6.2 um respectively. Neither of them was significantly related with sex, age, or AL. Both showed strong correlations with retinal thickness (r = 0.793, p = 0.000; r = 0.813, p = 0.000, respectively) and with similar topographic distributions within the retina. The thicknesses of retina and GCC/GCIPL in the inner sectors were significantly higher than in the outer sectors of the EDTRS area, while in the same region of the macula, the choroid exhibited completely different patterns of topographic variation. Men had 7.8 um thicker retina and 34.9 um thicker choroid than women after adjustment for age and AL (all p < 0.05). Age and AL could significantly influence the choroidal thickness but not the retina (all p < 0.05).ConclusionThickness of GCC/GCIPL in healthy Chinese individuals is not dramatically different across gender, age, and AL groups in terms of ETDRS grid, but sex is critical for retinal and choroidal thickness. Choroidal structure (but not retinal) can be significantly influenced by age and AL.Electronic supplementary materialThe online version of this article (doi:10.1186/s12886-015-0110-3) contains supplementary material, which is available to authorized users.
Highlights
To report the thickness of the retina, retinal ganglion cell (RGC)-related layers, and choroid in healthy subjects using swept source optical coherence tomography (SS-Optical coherence tomography (OCT))
The first objective of the present study is to evaluate ganglion cell complex (GCC)/ganglion cell-inner plexiform layer (GCIPL) thickness in the early treatment of diabetic retinopathy study (ETDRS) grid of healthy Chinese subjects
GCC/GCIPL, and choroidal thickness in healthy subjects Table 1 shows the actual numbers in each area of the ETDRS map
Summary
To report the thickness of the retina, retinal ganglion cell (RGC)-related layers, and choroid in healthy subjects using swept source optical coherence tomography (SS-OCT). Various retinal and choroidal pathologies, including age-related macular degeneration (AMD) and choroidal neovascularization (CNV), are among the most common reasons for severe visual impairment and blindness. For this reason, qualitative and quantitative analyses of retinal and choroidal structures are critical for the diagnosis and treatment of vitreo-retinal and choroidal diseases. Optical coherence tomography (OCT), as an essential tool in ophthalmology, can noninvasively capture detailed in vivo high resolution images of retinal and choroidal structures. This high resolution has enabled clinicians to accurately measure. Recent studies have demonstrated that GCC/ GCIPL thickness exhibit accurate detection of preperimetric glaucomatous damage when compared with the circumpapillary retinal nerve fiber layer [1, 6,7,8,9]
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