Abstract
BackgroundTo investigate macular retinal and choroidal thickness in amblyopic eyes compared to that in fellow and normal eyes using swept-source optical coherence tomography (SS-OCT).MethodsThis study examined 31 patients with hyperopic anisometropic amblyopia (6.9 ± 3.8 years, mean ± standard deviation), 15 patients with strabismic amblyopia without anisometropia (7.9 ± 4.2 years), and 24 age-matched controls (7.8 ± 3.3 years). Retinal and choroidal thickness was measured by 3D scans using SS-OCT. A 6-mm area around the fovea was automatically analyzed using the Early Treatment Diabetic Retinopathy Study map. The thickness from SS-OCT was corrected for magnification error using individual axial length, spherical refraction, cylinder refraction, and corneal radius. Retinal thickness was divided into the macular retinal nerve fiber layer (mRNFL), ganglion cell layer + inner plexiform layer (GCL+IPL), ganglion cell complex (GCC), and the inner limiting membrane to the retinal pigment epithelium (ILM-RPE) thickness. Retinal and choroidal thickness was compared among amblyopic, fellow, and normal eyes.ResultsIn both amblyopia groups, there was no significant difference in the mRNFL, GCL+IPL, and GCC thicknesses among the amblyopic, fellow, and control eyes. In the anisometropic amblyopia group, choroidal thickness (subfovea, center 1 mm, nasal and inferior of the inner ring, nasal of the outer ring, and center 6 mm) of amblyopic eyes were significantly greater than that of fellow and normal eyes. In contrast, none of the choroidal thicknesses were significantly different among the investigated eyes in the strabismic amblyopia group.ConclusionsWe found no significant difference in inner retinal thickness in patients with unilateral amblyopia. Although there were significant differences in choroidal thickness with hyperopic anisometropic amblyopia, there was no significant difference for the strabismic amblyopia. The discrepancy in choroidal thickness between the two types of amblyopia may be due to both differences in ocular size and underlying mechanism.
Highlights
To investigate macular retinal and choroidal thickness in amblyopic eyes compared to that in fellow and normal eyes using swept-source optical coherence tomography (SS-OCT)
Yen et al [10] reported that the circumpapillary retinal nerve fiber layer of refractive amblyopic eyes was thicker than that observed in the normal fellow eyes when using time-domain OCT
There was no significant difference in the macular retinal nerve fiber layer (mRNFL), ganglion cell layer + inner plexiform layer (GCL+IPL), and ganglion cell complex (GCC) thicknesses among the amblyopic, fellow, and normal control eyes for all of the sectors (Tables 2, 3, 4, 5, 6 and 7)
Summary
To investigate macular retinal and choroidal thickness in amblyopic eyes compared to that in fellow and normal eyes using swept-source optical coherence tomography (SS-OCT). An electrophysiological experiment reported finding a functional disturbance of the retina in human amblyopes [8]. Yen et al [10] reported that the circumpapillary retinal nerve fiber layer (cpRNFL) of refractive amblyopic eyes was thicker than that observed in the normal fellow eyes when using time-domain OCT. The OCT findings reported by Li et al [11] suggested that the foveal thickness in amblyopic eyes was greater than that in visually normal control eyes. It is still unclear as to why cpRNFL or foveal thickness in amblyopic eyes is thicker than that found in normal fellow eyes
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