Abstract
This paper presented the swelling properties of propranolol HCl-loaded polyvinyl alcohol-graft-lactic acid (PPH-loaded PVA-g-LA) hydrogel films. The swelling properties including swelling-deswelling measurement and swelling behaviour in different environmental stimuli fluids such as water, various pH, and various ionic strength were determined. It was found that the swelling properties of the PPH-loaded PVA-g-LA hydrogel films depend on the LA amount addition. They had a good swelling and deswelling in water and acetone. The PPH-loaded PVA-g-LA hydrogel films showed the high swelling in the medium pH 7. Thus, the prepared PPH-loaded PVA-g-LA hydrogel films had a good swelling property that could be used to controlled drug release in pharmaceutical product.
Highlights
The adhesive hydrogel films are polymer networks holding a significant amount of water whilst maintaining their structural integrity without dissolution whereas such thin films are adhering on human skin
The prepared propranolol HCl (PPH)-loaded Polyvinyl alcohol (PVA)-g-Lactic acid (LA) hydrogel films had a good swelling property that could be used to controlled drug release in pharmaceutical product
When increased the amount of the LA, it was found that the moisture content in the PPH-loaded PVA-g-LA hydrogel films increased, but at the maximum amount of the LA mixing found the decreasing of the moisture content in the PPH-loaded PVA-g-LA hydrogel films because the higher strength interaction between of ester bond between the hydroxyl groups of PVA and the carboxyl groups of LA might be obtained
Summary
The adhesive hydrogel films are polymer networks holding a significant amount of water whilst maintaining their structural integrity without dissolution whereas such thin films are adhering on human skin. They are ideal biocompatible materials that can be used as adhesives for several technologies and applications. Our previous publication reported the thermal properties including differential scanning calorimetry and thermogravimetric analysis, the confirmation of main functional groups by Fourier transform infrared spectroscopy, the swelling-deswelling behavior, and the moisture measurement per dry mass of modified polyvinyl alcohol-graft-lactic acid (PVA-g-LA) hydrogel films that synthesized by eco-friendly synthesis method [16]. The swelling behaviors were characterized by swelling-deswelling measurement and swelling behavior in different environmental stimuli fluids such as water, various pH, and various ionic strength
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