Abstract
Efflux of intracellular electrolytes and small organic solutes termed organic osmolytes is a universal response to cell swelling. While volume-activated ion efflux pathways have been studied extensively, relatively little was known until recently about the mechanisms and regulation of organic osmolyte release. An accumulating body of evidence, however, now indicates that structurally dissimilar organic osmolytes are lost from cells via a swelling-activated anion channel. We have termed this channel VSOAC for volume-sensitive organic osmolyte-anion channel. The purpose of this review is to summarize our current understanding of VSOAC and the process of volume regulatory organic osmolyte efflux.
Published Version
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