Abstract
The Tuberculosis is the classical human mycobacterial disease, caused by Mycobacterium tuberculosis. The disease primarily affect the lung and causes pulmonary tuberculosis, as well as affect intestine, bone, joints, meninges, lymph nodes, skin and other tissue of the body, causing extra pulmonary tuberculosis. Thus there arises the need to understand the relationships among various parameters of these proteins for prediction of their classes, structures and functionality. The computational approaches for prediction of their classes are fast and economical therefore can be used to complement the existing wet lab techniques. Realizing their importance, in this paper an attempt has been made to correlate them with their amino acid composition and predict them with fair accuracy. This is a novel method where Mycobacterium Tuberculosis has been classified on the basis of amino acid composition using Support Vector Machine. The SVM has been implemented using SVM Light package. The method discriminates different strains of Mycobacterium Tuberculosis. The performance of the method was evaluated using 10-fold cross-validation where accuracy of 100% was obtained.
Highlights
The German scientist (Robert Koch) announced that he had cultured the causative agent from human TB lesions and designated as “Bacillus of Tuberculosis”
About 90% of those infected with Mycobacterium tuberculosis have asymptomatic, latent TB infection, with only a 10% lifetime chance that a latent infection will progress to TB disease
Bacteria are picked up by dendritic cells, which do not allow replication, these cells can transport the bacilli to local lymph nodes
Summary
The German scientist (Robert Koch) announced that he had cultured the causative agent from human TB lesions and designated as “Bacillus of Tuberculosis”. About 90% of those infected with Mycobacterium tuberculosis have asymptomatic, latent TB infection (sometimes called LTBI), with only a 10% lifetime chance that a latent infection will progress to TB disease. TB infection begins when the mycobacteria reach the pulmonary alveoli, where they invade and replicate with the endosomes of alveolar macrophages. Bacteria are picked up by dendritic cells, which do not allow replication, these cells can transport the bacilli to local (mediastinal) lymph nodes. Further spread is through the bloodstream to other tissues and organs where secondary TB lesions can develop in other parts of the lung ( the apex of the upper lobes), peripheral lymph nodes, kidneys, brain, and bone. T lymphocytes secrete cytokines such as interferon gamma, which activates macrophages to destroy the bacteria with which they are infected. Cytotoxic T cells can directly kill infected cells, by secreting perforin and granulysin [3,4]
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