Abstract
Diabetes mellitus (DM) is a chronic disease and it is called as a silent killer because this disease is unrecognized by the diabetics. However, when it is already known the complication is occurred. It is recognized by the increase of blood glucose level (hyperglycemia) as the main character of Diabetes Mellitus (DM). This condition causes the increase of the Reactive Oxygen Species (ROS) in a chronic condition. Then, insulin resistance is caused by the oxidative stress in fat, muscle and liver tissue. Moreover, insulin resistance produces several oxidative stress mediators including (TNF- α). This research aims to determine the effect of suweg flour (Amorphophallus campanulatus) on TNF-α level in rats diabetic model. The method used in the research was an experimental laboratory of pre-post control group test conducted in 28 days. The subjects of this research were 25 Rattus Novergicus wistar strains, (P1) positif control (P2), standart (P3) and two treatment groups (P4 and P5). The data were gained by measuring the level of TNF-α before and after receiving the suweg flour enzyme-linked immunosorbent assay (ELISA). The data were analyzed by paired sample t-test. This research showed a significant correlation between suweg flour and TNF-α levels (p = 0.000). A significant correlation was discovered in all treatment groups (P4 and P5). The results of this research can be concluded that the administration of suweg flour ( Amorphophallus campanulatus ) can decrease of TNF-α levels in rats diabetic model.
Highlights
Diabetes mellitus (DM) is a group of noncommunicable and chronic diseases
Diabetes Mellitus is a metabolic disease characterized by hyperglycemia due to abnormal insulin secretion, insulin action, or both
Diabetes Mellitus is an inflammatory disease caused by the increase of serum cytokine levels such as IL-6 IL-18, IL-1, and Tumor necrosis factor-α (TNF-α)
Summary
Diabetes mellitus (DM) is a group of noncommunicable and chronic diseases. This disease is often found throughout the world and the number of this case is predicted to increase over time. (463 million people) increased to 10.2% (578 million people) in 2030 and 10.9% (700 million people) in 2045.1,2 The prevalence of Diabetes Mellitus in the world in 2014 was 8.5% with 424 million survivors and it was expected to increase over time.[3]. Diabetes Mellitus can cause complications such as microvascular and macrovascular complications including coronary artery disease and peripheral arterial disease.[4,5]. Diabetes Mellitus is an inflammatory disease caused by the increase of serum cytokine levels such as IL-6 IL-18, IL-1, and TNF-α.6. Hyperglycaemia and Oxidative stress activate the immune system and create an inflammatory medium by the activation of the nuclear transcription factors-kappa B (NF-kB), and release of inflammatory cytokines (TNF-α).[8]
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