Abstract
A long-acting insulin preparation involving the sustained release of biologically active insulin from a hydrophilic ethylene-vinyl alcohol (EVAl) matrix was developed. A single subcutaneous implant of this insulin lowered the blood glucose levels of diabetic rats for more than one month. These results suggest that a long-acting insulin may be produced by the entrapment of insulin within a hydrophilic EVAl copolymer matrix.
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