Antidiabetic activity of herbal green tea extract from white mangrove (Avicennia marina) leaves towards blood glucose level of diabetic wistar rats (Rattus novergicus)

Bambang B Sasmito,Hardoko Hardoko,Binti Nafi’Ah,Yuniwaty Halim

doi:10.7455/ijfs.v8i2.553

Bambang B Sasmito, Hardoko Hardoko + Show 2 more

Open Access

https://doi.org/10.7455/ijfs.v8i2.553

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Abstract

Green tea Camellia sinensis contains polyphenol that has antidiabetic activity. Mangrove leaves also contain polyphenol which potentially gives these leave antidiabetic activity. The aim of this research was to determine the ability of herbal green tea extract from white mangrove (Avicennia marina) leaves to decrease blood glucose level of diabetic Wistar rats (Rattus novergicus). The method used was experimental and involved giving a herbal green tea extract from white mangrove leaves with concentration of 100, 200 and 300 mg/200g BW/day, and positive control, i.e. glybenclamid (0.09 mg/200 g BW/day), to diabetic rats injected with Streptozotocin (STZ) and Nicotinamide (NA). The rats were observed on day 0, 5, 10 and 15. The results showed that the herbal green tea extract from white mangrove leaves decreased the blood glucose level of diabetic rats. The effective extract dose that decreased the blood glucose level of diabetic rats was 300 mg/200 g BW, which is comparable to the effect produced by glybenclamid (antidiabetic medicine). This dose could decrease the blood glucose level of diabetic rats to reach a normal blood glucose level after 20 days.

Highlights

Diabetes mellitus is an endocrine condition that is caused by the decrease of insulin effectivity, i.e. a hormone that plays a role in the carbohydrate metabolism
The experimental methods involved adminstering a dose of extract of green tea from white mangrove (A. marina) leaves extract to diabetic rats, with negative control and positive control.The dosed rats were sampled at different times
The blood glucose level before and after induction with STZ and NA can be observed on Table 1

Summary

Introduction

Diabetes mellitus is an endocrine condition that is caused by the decrease of insulin effectivity, i.e. a hormone that plays a role in the carbohydrate metabolism. Insufficient insulin secretion causes blood glucose level to exceed the normal acceptable physiological limit. Chronic high blood glucose levels causes nerve, blood vessel and coronary artery damage. This condition increases coronary disease risk, stroke, kidney failure and other disease complications (Fadilah, 2017). Diabetic treatment generally involves dietary management and the use of synthetic chemical drugs or natural traditional medicine. The treatment using chemical drugs is considered less safe because of its unwanted side effects. Treatment using traditional medicine is considered safer because it has less side effects; many diabetic patients are interested in it. Green tea is used to decrease obesity (Purwanto, Darmawati, Purwaningsih, & Ners, 2014; Rahmanisa & Wulandari, 2016; Sari, 2015), dia-

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