Abstract
This article introduces a highly proficient and environmentally friendly process for producing pyranopyrazole-5- carbonitriles with outstanding yields. This involves a multicomponent synthesis using commonly available aldehydes, malononitrile, ethyl acetoacetate, and phenylhydrazine, conducted in ethanol with perchloric acid supported on silica (HClO4-SiO2) as a solid catalyst. Utilizing HClO4-SiO2 as a reusable catalyst underscores the sustainability of this approach, offering a valuable green chemical strategy for pyranopyrazole synthesis. Characterization of the synthesized compounds was achieved using FTIR, 1H NMR, 13C NMR, and Mass spectrometry. Additionally, molecular docking studies revealed significant binding energies of the compounds to receptor-active sites, further validating their potential pharmacological relevance.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
