SUSTAINABLE CONSTRUCTION OF PYRANOPYRAZOLES UTILIZING HClO4-SiO2 AS AN EFFICIENT SOLID CATALYST AND DOCKING STUDIES

Abstract

This article introduces a highly proficient and environmentally friendly process for producing pyranopyrazole-5- carbonitriles with outstanding yields. This involves a multicomponent synthesis using commonly available aldehydes, malononitrile, ethyl acetoacetate, and phenylhydrazine, conducted in ethanol with perchloric acid supported on silica (HClO4-SiO2) as a solid catalyst. Utilizing HClO4-SiO2 as a reusable catalyst underscores the sustainability of this approach, offering a valuable green chemical strategy for pyranopyrazole synthesis. Characterization of the synthesized compounds was achieved using FTIR, 1H NMR, 13C NMR, and Mass spectrometry. Additionally, molecular docking studies revealed significant binding energies of the compounds to receptor-active sites, further validating their potential pharmacological relevance.