Sustainable Catalytic Process with a High Eco‐scale Score for the Synthesis of Novel Series of Bischalcones through Claisen–Schmidt Condensation

Abstract

An efficient, sustainable, and green method for the synthesis of novel series of bischalcones was developed using an environmentally benign ionic liquid as catalyst under ultrasound irradiation. This new catalyst affords diverse bis‐α, β‐unsaturated ketones in excellent yields under ambient reaction conditions in water. Moreover, the catalyst found to be active down to 15 mol% and affords the products with up to 96% yield. The process is eco‐sustainable since this ionic liquid is ease of recovery and reuse for at least five successive cycles without diminishing of the yield and catalyst leaching. Other merits of this protocol comprise its operational simplicity, short reaction time, non‐chromatographic purification procedure, and wide functional groups tolerance. Furthermore, this catalytic system is applicable for the gram‐scale preparation of bischalcones, scoring well in a number of green metrics.