Abstract
Zinc linked amino acid complex, Zn(l‐proline)2, is considered as a green catalyst for the synthesis of novel series of pyrimidine derivatives5a–q.The pyrimidines5a–qwere prepared via two pathways: the first is a one‐pot reaction of guanidines3a–cwith aromatic aldehyde1and acetophenones2; and the second one is the reaction of guanidines3a–cwith different chalcones4a–jin aqueous medium. The simplicity of the operation, the short reaction time, and the high efficiency (97%) are the main advantages of this protocol. Furthermore, the green aspects of this synthetic protocol were further investigated by examining the reusability of Zn(l‐proline)2complex throughout five consecutive cycles without a significant loss of catalytic activity. This new procedure has presented remarkable advantages in terms of safety, simplicity, stability, mild conditions, a short reaction time, excellent yields, and high purities without using any organic solvents.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
