Synthesis of aminomethylphenol derivatives via magnetic nano $$\hbox {Fe}_{3}\hbox {O}_{4}$$ Fe 3 O 4 catalyzed one pot Petasis borono-Mannich reaction

Abstract

A novel library of aminomethylphenol has been developed using magnetic $$\hbox {Fe}_{3}\hbox {O}_{4}$$ nanoparticles via Petasis borono-Mannich reaction of salicylaldehydes, secondary amines and phenyl boronic acids. This one-pot protocol features mild reaction conditions, excellent yields in short reaction times, readily available starting materials, good functional group tolerance and reusability of the catalyst for four consecutive cycles without significant loss in its activity. A novel library of aminomethylphenol has been developed using magnetic $$\hbox {Fe}_{3}\hbox {O}_{4}$$ nanoparticles via Petasis borono-Mannich reaction of salicylaldehydes, secondary amines and phenyl boronic acids. This one-pot protocol features mild reaction conditions, excellent yields in short reaction times, readily available starting materials, good functional group tolerance and reusability of the catalyst for four consecutive cycles without significant loss in its activity.