Abstract
SummaryMale and female mice were tested for their susceptibility to the nephro-toxic properties of chloroform and 1,1,2-trichloroe thane. Renal dysfunction, as determined by phenolsulfonephthalein excretion was demonstrated in male mice with chloroform at 0.078 ml/kg and 0.17 ml/kg for 1,112-trichloroethane. Renal dysfunction could not be produced in female mice with chloroform and 1,1,2-trichloroethane, even at lethal doses. Male and female mice were also tested for their susceptibility to the hepatotoxic properties of carbon tetrachloride. Liver dysfunction, as determined by elevated serum glu-tamic-pyruvic transaminase activity, could be demonstrated in both male and female mice at 0.009 ml/kg. No sex difference was observed in the 24-hour LD50 values for the three agents tested. This indicates that with these agents nephrotoxicity is not an important contributing factor in the deaths occurring during the first 24 hours.
Published Version
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