Abstract
microtubule during the G2/M phase of cell cycle, thereby hin-dering the formation of a bipolar spindle during mitosis and, consequently, causing a mitotic catastrophe. According to the results of the authors’ research, one of the working mechanisms of oxaliplatin may be that it not only causes apoptosis by inhib-iting the expression of survivin but also impedes the formation of a bipolar spindle during mitosis as survivin fails to be posi-tioned normally in the microtubule because it is not expressed properly in the microtubule or the contractile ring when the cells have reached the interphase of the cell cycle. The authors’ study is considered meaningful in that it con-tributes to an explanation of the molecular effect of oxalipla-tin, which is used most commonly in chemotherapy for colon cancer. These data indicate that survivin may be a key target for oxaliplatin. The ability of oxaliplatin to induce different modes of cell death may contribute to its efficacy in treating colorectal cancer.
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