Survivin as a Novel Biomarker in the Pathogenesis of Acne Vulgaris and Its Correlation to Insulin-Like Growth Factor-I.

Hanan A Assaf,Mohamed A Adly,Wafaa M Abdel-Maged,Bakheet E M Elsadek,Soher A Ali,Mohammed H Hassan

doi:10.1155/2016/7040312

Hanan A Assaf, Mohamed A Adly + Show 4 more

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https://doi.org/10.1155/2016/7040312

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Abstract

Survivin, a member of the inhibitor of apoptosis protein family, has an important role in cell cycle regulation. Insulin-like growth factor-I (IGF-I) is a polypeptide hormone with wide range of biologic effects including stimulation of lipogenesis in sebaceous glands. Their overexpression in some fibrotic disorders suggests a possible implication of both IGF-I and survivin in the pathogenesis of acne and/or acne scars. The current study aimed to assess and correlate serum levels of IGF-I and survivin in patients with active acne vulgaris and postinflammatory acne scars and to evaluate their lesional expressions in comparison to healthy controls. Serum IGF-I and survivin were estimated using commercially available ELISA kits and their tissues expressions were investigated using Western blotting. Our findings suggest that IGF-I and survivin could play potential roles in the pathogenesis of active acne vulgaris and more importantly in postinflammatory acne scars with significant positive correlation coefficient between serum levels of IGF-I and survivin which support IGF-I-/PI3K-/AKT-mediated downregulation of nuclear expression of FoxO transcription factors resulting in enhanced survivin expression.

Highlights

Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit, characterized by seborrhea, formation of comedones, erythematous papules, and pustules and less frequently by nodules, deep pustules, or pseudocysts [1]
Prior to initiation of the study, every subject was informed about the aim of the study and was given a written consent for participation. They were classified into three groups; the first group included 15 patients suffering from active acne and did not receive any treatment for 3 months; the second group included 15 patients suffering from postinflammatory acne scars with no history of previous skin resurfacing, no active infection, and with no use of oral isotretinoin in the previous 6 months; and the third group consisted of 15 healthy subjects to serve as a control group
Our results have shown that the circulating levels of Insulin-like growth factor-I (IGF-I) were obviously elevated in the active acne and acne scar groups in comparison to the healthy control group with a remarkable increase in acne scar group compared to active acne group (Table 1 and Figure 1(a))

Summary

Introduction

Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit, characterized by seborrhea, formation of comedones, erythematous papules, and pustules and less frequently by nodules, deep pustules, or pseudocysts [1]. The primary and the pathognomonic lesion of acne is microcomedo, a microscopic lesion invisible to the eye, which evolves commonly into inflammatory or noninflammatory lesions. The formation of microcomedo requires complex interplay of altered follicular keratinization, hyperplasia of sebaceous glands, and overcolonization of sebaceous glands with Propionibacterium acnes [2]. Acne has prevalence over 90% [3] and persists into adulthood in approximately 12%–14% of cases with psychological and social implications [4]. The scarring process can occur at any stage of acne [6]

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