Changes and correlations of serum and CSF insulin-like growth factor-I levels in neonates with hypoxic-ischemic encephalopathy

Abstract

Objective To investigate the changes and correlations of serum and cerebrospinal fluid(CSF)insulin-like growth factor-Ⅰ(IGF-Ⅰ)levels in neonates with hypoxic-ischemic encephalopathy(HIE)and to investigate its effects on HIE. Methods Both serum and CSF IGF-Ⅰ levels in 41 neonates with HIE and serum IGF-I levels in 10 normal neonates were measured by RIA at 12〜24 hrs and 10〜12 ds of life. Results (1)During postnatal 12〜24 hrs, the serum IGF-I levels were 32. 94±8. 43ng/ml, 22. 56 ± 5. 51ng/ml and 15. 77 ± 3. 60ng/ml in mild, moderate and severe HIE groups, respectively, which were significantly lower than those in control group(79. 28±13. 28 ng/ml)(P 0. 05). The CSF IGF-Ⅰ levels were 6. 18 ± 0. 87 ng/ml in mild, 5. 74 ± 0. 94 ng/ml in moderate and 5. 08 ± 0. 87 ng/ml in severe HIE group who have no neurological symptoms or signs respectively at postnatal 10-12days, which were significantly increased compared with their levels at postnatal 12〜24 hrs(4. 43±1. 16 ng/ml, 3.19 ± 0. 84ng/ml, 1.97 ± 0. 45ng/ml, respectively)(P 0. 05).(3)A positive correlation were shown between the serum and CSF IGF-Ⅰ levels in HIE groups(r= 0. 84, P<0. 05). Conclusion IGF-Ⅰ is an important neuroprotective factor and it's changes of levels in serum and in CSF might be associated with the pathogenesis and prognosis of neonatal HIE. Key words: insulin-like growth Factor-Ⅰ(IGF-Ⅰ); cerebral anoxia; cerebral ischemia; neonate