Survival and related factors of 1 177 HIV/AIDS patients with antiretroviral therapy in Beijing

Abstract

Objective To analyze the survival time and related factors of 1 177 HIV patients receiving antiretroviral therapy in Beijing. Methods A retrospective cohort study was conducted to analyze the data that collected from the National HAART Reporting System during January 1, 2012 to December 31, 2015. Life table method was applied to calculate the survival proportion. Kaplan-Meier method was used to calculate the average survival time at the end of observation. Cox proportion hazard regression model was used to identify the factors related to survival time. Results A total of 1 177 cases were selected. The average survival time was 47.45 months (95%CI 47.18-47.72), and the overall mortality rate was 0.43 per 100 person-year. The survival rates at 1st, 2nd, 3rd and 4th year were 98.96%、98.69%、98.59% and 98.59%, respectively. Multivariate Cox regression analysis showed that patients’ age (≥50 years) (HR=28.98, 95%CI 3.18-263.94), transmission by intravenous drug use (HR=22.60, 95%CI 5.07-100.78) and baseline CD4+ T cell count of 0-50/μL comparing to >200/μL (HR=14.23, 95%CI 2.67-75.90), at antiretroviral therapy initiation had significant effect on patients survival. Conclusions The antiretroviral therapy in Beijing reduced the mortality rate, prolonged the survival time, and was significantly effective. The related factors were transmission route, patients’ age and CD4+ T cell counts when antiretroviral therapy began. Key words: Acquired immunodeficiency syndrome; Antiviral agents; HIV long-term survivors; Statistical; Factor analysis