Abstract
Objective To conducte survival analysis of synchronous colorectal liver metastases(SCRLM). Methods Retrospectively collected clinicopathologic data of 1061 SCRLM patients, and then conducted univariate and Cox regression analyses. Results For patients with resectable SCRLM, synchronous resection could reduce the expense compared with asynchronous resection, while there were no significant differences in short-term complications or long-term survival.For asymptomatic unresectable SCRLM patients, resection of primary tumor could improve long-term survival.Poor differentiation of primary tumor, number of liver metastases≥4, maximum liver metastasis≥5 cm, extra-liver metastases, no resection of primary tumor and no surgical treatment of liver metastases were independent prognosis factors.Giving one point to each above factor, all SCRLM patients were divided into low-risk(0~1), medium-risk(2~3)and high-risk(4~6)groups which 5-year-survival rates are 51%, 16% and 0% respectively. Conclusions In patients with resectable SCRLM, synchronous resection of primary tumor and liver metastases was the optimal choice.In asymptomatic patients with unresectable SCRLM, resection of primary tumor was recommended at the right time.The prediction model should be used to guide clinical management of SCRLM patients. Key words: Colorectal neoplasms; Neoplasm metastasis; Colorectal surgery; Prognosis
Published Version
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