Abstract
Objective To analyze the drug resistance and detect the drug resistance genes of pathogenic bacteria isolated from hospital sewage, and to investigate the sources of antibiotic resistant microorganisms in the environment. Methods The enteric pathogenic bacteria, such as thermotolerant Escherichia coli, Salmonella and Shigella, were isolated from the sewage of Shaoxing hospitals from January 2016 to December 2016, and the detection of drug resistance of thermotolerant Escherichia coli, the drug resistance of Escherichia coli isolated from clinical specimens of three hospitals was compared and analyzed. Meanwhile, extended spectrum beta lactamases (ESBLs) resistance genes were detected in thermotolerant Escherichia coli in sewage. Results 48 strains of pathogens were isolated in sewage, including 32 strains of Escherichia coli, 2 strains of Shigella sonnei and 1 strain of Salmonella arizonae. Escherichia coli has a low rate of resistance to most antibiotics. Compared to Escherichia coli isolated from clinical specimens, there were significant differences among the drug resistance rates of Ampicillin, Aztreonam, Amoxicillin/Clavulanic acid and the first to four generation Cephalosporins (P<0.05). 11 strains of ESBLs positive bacteria were detected in sewage. Among them, 7 carried CTX-M9 resistance genes, and 4 carried TEM resistance genes, while 1 strain of CTX-M1 and SHV was carried. There were 2 strains carrying CTX-M9 and TEM resistance genes simultaneously, 1 strain simultaneously carrying TEM and SHV resistance genes. Conclusions There are different kinds of intestinal pathogens in hospital sewage, which may lead to contamination of drug-resistant microorganisms in the environment. Therefore the hospitals should strengthen the quality of sewage treatment and improve the qualified rate of sewage disinfection. Key words: Hospital sewage; Microorganism; Survey; Drug resistance; Thermotolerant Escherichia coli
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