Abstract
Gastroesophageal reflux disease is the major indication for surgical therapy in benign esophageal disease. The efficiency of fundoplication to control reflux by restoration of a defective lower esophageal sphincter is confirmed by several studies. Attention needs to be paid to technical details to avoid undue side effects or failures. Barrett's esophagus is increasingly recognized as end-stage reflux disease characterized by high esophageal acid and alkaline exposure and poor esophageal motor function. The effects of antireflux surgery on preventing the malignant degeneration of the abnormal mucosa is unclear. Early carcinoma can be cured by surgical resection. Surgical resection remains the mainstay of therapy for esophageal cancer. En-bloc resection in patients with early tumors appears to have the best potential for cure. In uncontrolled trials, multimodality treatment of esophageal cancer improves resectability but has minimal effect on survival rates.
Published Version
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