Abstract
BACKGROUND: The incidence of colon carcinoma has increased during the last years, but novel diagnostic tools have also been developed. METHODS: Review on colon carcinoma. RESULTS: The only chance in the cure of colonic carcinoma is achieved by radical surgery (R0-resection). Prognosis of advanced carcinomas may improve with chemotherapy, although the efficiency of neoadjuvant designs has not yet been confirmed. Taking into account the intramural microscopic tumor spread, a safety margin of 5 cm seems to be sufficient for circumferentially growing tumors. The extent of colonic resection is defined by the resection of the blood vessels as well as its lymphovascular excision. Prognosis of colonic cancer depends on the tumor stage at the time of diagnosis as well as on the experience of the operating surgeon. In addition, TNM stage and tumor grading are very important factors, too, regarding prognosis. The impact of molecular markers of tumor tissue and serum are still being discussed. CONCLUSIONS: Radical surgical resection can yield good results in the treatment of colon carcinoma.
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