Surfactants interaction with sulfathiazole: Spectroscopic, conductometric, and thermodynamic approach

Abstract

Taking into the account the advantages of surfactant micelles as drug carrier, the interaction of sulfathiazole (STZ) with three types of surfactants, namely, cationic cetyltrimethylammonium bromide (CTAB), anionic sodium dodecyl sulfate (SDS), and non-ionic t-octylphenoxypolyethoxyethanol (TX-100) has been studied by using UV–visible spectroscope and conductivity measurements. The critical micelle concentration (CMC), degree of ionization (α), counter ion binding constant (β), free energy change of micellization (ΔG0m), relative solubility (St/S0), STZ-surfactant interaction constant (θ), approximate number (n) of STZ molecules incorporated per micelle, heat capacity (ΔC0m), and transfer of thermodynamic parameters were calculated and discussed for both the systems. The CMC values of CTAB and SDS were found to decrease in presence of increasing STZ concentrations. The values of counter ions dissociation were also found to be dependent of temperature. The ΔG0m values are obtained to be negative of both systems. A comparison of the binding constants (KC) calculated from the Kawamura equation indicated that the solubilization tendency of STZ with CTAB is much higher than that with SDS micelles. However, this interaction was weak since no significant change in the micellization phenomenon was observed with TX-100 under our experimental conditions.