Abstract
This paper reports an ultrasensitive surface-enhanced Raman spectroscopy (SERS) for detecting and identifying four kinds of DNA bases: adenine, cytosine, thymine, and guanine using a gold nanoparticle dimer. The gold nanoparticle dimer was directionally arrayed on a substrate in order to achieve huge enhancement according to the polarization-dependent enhancement. 10−11 M limit of detection for four DNA bases and 0.1 s rapid detection for adenine were achieved. Additionally, a separated single dimer was fabricated and evaluated. We clarified single-molecule-level SERS detection and identification was possible using the locally enhanced single hotspot of the single dimer with the 1-nm nanogap.
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