Abstract
This paper reports surface-enhanced Raman spectroscopy (SERS) analysis of a single DNA oligomer toward SERS-based reliable DNA sequencing using a single gold nanoparticle dimer. Due to the Raman enhancing hotspot with 1-nm nanogap in the single dimer, for the first time, the single oligomer detection and analysis was demonstrated. The dimer identified the several bases and backbone components of the single DNA oligomer. The dynamics of the single oligomer could be analyzed. The oligomer was trapped and stayed at the nanogap hotspot, and fluctuated with rotation.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
