Surface plasmon resonance sensing technology and its application in clinical diagnose

Abstract

Surface plasmon resonance (SPR) sensor technology, with its features of real-time, fast, no need for labeling, no background interference and non-destructive to samples, etc., has been widely used in the field of biotechnology, medicine, environmental science and drug detection. This article gives an overview of the recent popular studies and their progress in SPR technology is reviewed, especially giving a detailed overview of the surface modification technique, related hyphenated techniques and application of SPR in clinical examination. Hyphenated techniques is discussed from three aspects of molecular imprinting technique, SPR based immunoassay and nucleic acids SPR biosensor as well. Key words: Surface plasmon resonance sensor; Biosensor; Surface modification technique; Clinical examination