Abstract
Surface modification of metallic and inorganic materials with femtosecond laser irradiation for biomedical applications is reviewed in this chapter. Titanium (Ti) and titania (TiO2) were selected as the models for metallic and inorganic substrates, respectively. Femtosecond laser scanning successfully creates unique periodic surface topography on various materials through a one-step process. Present data showed that surface modification with a femtosecond laser had scale-independent effects on the surface chemical properties and biocompatibility. By controlling the unique periodic surface topography, surface wettability could be changed, and cell adhesion, proliferation, differentiation, calcification, and hemocompatibility could be regulated in vitro. A relative in vivo study also showed that this unique hierarchical periodic topography by femtosecond laser surface modification could also be effective regulating the biocompatibility of the metallic and inorganic material with bone tissues. It was revealed that surface modification with a femtosecond laser can be an effective technology to create unique hierarchical periodic surface topography on metallic and inorganic materials. Moreover, the scale of surface topography can be controlled with a one-step modification and has positive effects in controlling the biocompatibility, which is predicted to be very useful for further medical applications.
Published Version
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